Bio-Sensitive ASICs for Smart Sensors in Medical and Environmental Monitoring


B-ASICS - 6240

Keywords biological sensors, chemical sensors, integrated sensors, protein sensors, voltammetry, environmental monitoring, medical diagnostics


Start Date: 01-JUN-92 / Duration: 39 months

[ contact / participants ]


Objectives

The B-ASICS project aims to develop biological and chemical sensors for clinical and environmental applications, and in particular, methods to directly determine antibody-antigen reactions for rapid clinical screening and to determine metal ion concentration in fresh water for industrial effluent monitoring. The target is to develop low-cost, easy-to-use technologies which combine the power of microelectronics with advances in chemistry and microbiology to achieve the project's goals. The process technology will be a 1.5 micron CMOS technology, supporting an extensive analogue and digital cell library and special process modifications for such devices as ISFETs.

Progress and Results

Chemical sensing principles and techniques required for measuring metal ions in industrial effluents have been demonstrated to ppb sensitivity limits and with more than adequate specificity for the metals of interest (Cd, Zn, Pb and Cu). Detailed component and system designs have been started. The general target is a portable PC based instrument for easy use in the field.

Work is also underway on developing techniques for direct measurement of proteins using microelectronics-compatible technology. Concentrating on capacitive detection methods, the consortium has made major progress in binding proteins to semiconductor-compatible surfaces and then determining the presence of antibody-antigen immunological reactions. Simulation studies of the protein/fluid/sensor surface is being used to understand these complex reactions. Compatibility of the techniques with microelectronics "back-end" processes and specialised packaging techniques for such sensors are also being addressed.


CONTACT POINT

Prof Bill Lane
National Microelectronics Research Centre
Prospect Row
IRL - Cork
tel: + 353 / 21-276-871
fax: + 353 / 21-270-271

Participants

NATIONAL MICROELECTRONICS
RESEARCH CENTRE - IRL - C
CRANFIELD BIOTECHNOLOGY LTD - UK - P
FRESHWATER BIOLOGICAL ASSOCIATION - UK - P
ZENTRUM MIKROELEKTRONIK DRESDEN - D - P
DAIMLER-BENZ AG - D - P
FRAUENKLINIK


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B-ASICS - 6240, December 1993


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html version of synopsis by Nick Cook